By Rail
The nearest railhead is a half hour away at Chiusi from where there are frequent trains to Florence and Rome.
By road
By road
Montepulciano is a few miles from the A1 Autostrada as well as the more scenic SS2 from Rome to Florence. Cars are not allowed inside the historical old town except with a permit, available from hotels so park in one of the numerous lots at the edge of the town. Be warned that the lots fill up quickly in late summer, the height of the tourist season.
By bus
By bus
Buses, departing from Piazza Pietro Nenni, connect Montepulciano with many other Tuscan cities: Siena 75 minutes, 4/day none on Sunday, Pienza 30 minutes, 8/day, Montalcino 1 hour 10/day, change in Torrenien and Chiusi hourly. Route #146 into Montepulciano is quite scenic.